Epitalon (Epithalon) 20mg· 20mg

The proposed mechanism of action of epitalon has been described by the Khavinson group as involving direct DNA binding at specific promoter regions, with consequent modulation of gene expression. Reported effects on telomerase activity in cultured human somatic cells, including human fibroblasts and lymphocytes, have been attributed to upregulation of the TERT catalytic subunit promoter. This proposed mechanism is distinctive among bioactive peptides and remains incompletely characterized in independent peer-reviewed studies outside the Khavinson research program.

Additional reported effects include modulation of melatonin secretion from pineal gland preparations, suggesting an action on pineal endocrine function. In rodent studies, the peptide has been associated with normalization of circadian rhythm parameters and with extension of median and maximum lifespan in some experimental designs. The relationship between proposed gene-regulatory effects and observed physiological phenotypes remains an active area of research interpretation, with continued characterization needed to integrate molecular and organismal observations.