Kisspeptin-10 5mg· 5mg

Kisspeptin-10 binds the kisspeptin receptor KISS1R (also known as GPR54), a class A G-protein coupled receptor coupled to Gq. Receptor engagement activates phospholipase C-beta, generating inositol trisphosphate and diacylglycerol, with downstream mobilization of intracellular calcium and activation of protein kinase C.

KISS1R is expressed at high levels on hypothalamic GnRH neurons, where receptor activation depolarizes the cell, increases firing frequency, and triggers GnRH release from axon terminals in the median eminence. The resulting GnRH pulse stimulates gonadotrope release of luteinizing hormone and follicle-stimulating hormone from the anterior pituitary, with downstream effects on gonadal function. Kisspeptin neurons in the arcuate nucleus (sometimes designated KNDy neurons for their co-expression of neurokinin B and dynorphin) form the principal GnRH pulse generator network, integrating sex steroid feedback, metabolic signals, and circadian input to coordinate reproductive endocrine output.