Sermorelin 5mg· 5mg

Sermorelin binds the GHRH receptor, a class B G-protein coupled receptor expressed on pituitary somatotrophs and at lower levels in extra-pituitary tissues including the hypothalamus and pancreas. Receptor engagement activates Gas, elevates intracellular cAMP, and stimulates protein kinase A-dependent transcription of the growth hormone gene as well as exocytosis of stored hormone from somatotroph secretory granules.

The native GHRH sequence is cleaved at the position 2 Ala-Asp bond by dipeptidyl peptidase-4, yielding the inactive GHRH (3-29) metabolite within minutes of administration. This rapid clearance limits sermorelin to short receptor-exposure durations, producing single growth hormone pulses with each administration. The pulse pattern recapitulates the dynamics of endogenous GHRH release more faithfully than long-acting analogs, an advantage in research contexts where pulsatile rather than sustained somatotroph activation is desired.